Manoharan, Muthiah : rechercher sur Z-Library

Le plus grand référentiel d'articles scientifiques au monde. 70,000,000+ d'articles gratuitement.

Don't use scam websites

Livres
Articles (183)
Les plus populaires
Liste
- Liste
- Tableau

1

Advanced siRNA Designs Further Improve in vivo Performance of GalNAc-siRNA Conjugates

Foster, Donald J., Brown, Christopher R., Shaikh, Sarfraz, Trapp, Casey, Schlegel, Mark K., Qian, Kun, Sehgal, Alfica, Rajeev, Kallanthottathil G., Jadhav, Vasant, Manoharan, Muthiah, Kuchimanchi, Sat

Journal:

Molecular Therapy

Année:

2018

Langue:

english

Fichier:

PDF, 1.25 MB

english, 2018

2

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akinc, Akin, Maier, Martin A., Manoharan, Muthiah, Fitzgerald, Kevin, Jayaraman, Muthusamy, Barros, Scott, Ansell, Steven, Du, Xinyao, Hope, Michael J., Madden, Thomas D., Mui, Barbara L., Semple, Sea

Journal:

Nature Nanotechnology

Année:

2019

Fichier:

PDF, 1.45 MB

2019

3

An efficient deprotection method for 5′-[O,O-bis(pivaloyloxymethyl)]-(E)-vinyl phosphonate containing oligonucleotides

O'Shea, Jonathan, Theile, Christopher S., Das, Rajat, Babu, I. Ramesh, Charisse, Klaus, Manoharan, Muthiah, Maier, Martin A., Zlatev, Ivan

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 977 KB

english, 2018

4

X-ray crystallographic analysis of the hydration of A- and B-form DNA at atomic resolution

Martin Egli, Valentina Tereshko, Marianna Teplova, George Minasov, Andrzei Joachimiak, Ruslan Sanishvili, Charles M. Weeks, Russ Miller, Martin A. Maier, Haoyun An, P. Dan Cook, Muthiah Manoharan

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 1.04 MB

english, 1998

5

Unique Gene-Silencing and Structural Properties of 2′-Fluoro-Modified siRNAs

Dr. Muthiah Manoharan, Dr. Akin Akinc, Dr. Rajendra K. Pandey, June Qin, Dr. Philipp Hadwiger, Dr. Matthias John, Kathy Mills, Dr. Klaus Charisse, Dr. Martin A. Maier, Dr. Lubomir Nechev, Emily M. Gre

Journal:

Angewandte Chemie International Edition

Année:

2011

Langue:

english

Fichier:

PDF, 783 KB

english, 2011

6

Lipidic nucleic acids

Muthiah Manoharan, Kathleen L. Tivel, P.Dan Cook

Journal:

Tetrahedron Letters

Année:

1995

Langue:

english

Fichier:

PDF, 238 KB

english, 1995

7

Reversed-phase high-performance liquid chromatography method for simultaneous analysis of two liposome-formulated short interfering RNA duplexes

Veeravagu Murugaiah, William Zedalis, Gary Lavine, Klaus Charisse, Muthiah Manoharan

Journal:

Analytical Biochemistry

Année:

2010

Langue:

english

Fichier:

PDF, 544 KB

english, 2010

8

RNA interference and chemically modified small interfering RNAs

Muthiah Manoharan

Journal:

Current Opinion in Chemical Biology

Année:

2004

Langue:

english

Fichier:

PDF, 271 KB

english, 2004

9

Cholic acid-oligonucleotide conjugates for antisense applications

Muthiah Manoharan, Laura K. Johnson, C.Frank Bennett, Tim A. Vickers, David J. Ecker, Lex M. Cowsert, Susan M. Freier, P. Dan Cook

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1994

Langue:

english

Fichier:

PDF, 492 KB

english, 1994

10

Silencing of microRNAs in vivo with ‘antagomirs’

Krützfeldt, Jan, Rajewsky, Nikolaus, Braich, Ravi, Rajeev, Kallanthottathil G., Tuschl, Thomas, Manoharan, Muthiah, Stoffel, Markus

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 451 KB

english, 2005

11

Lipophilic siRNAs mediate efficient gene silencing in oligodendrocytes with direct CNS delivery

Qingmin Chen, David Butler, William Querbes, Rajendra K. Pandey, Pei Ge, Martin A. Maier, Ligang Zhang, Kallanthottathil G. Rajeev, Lubomir Nechev, Victor Kotelianski, Muthiah Manoharan, Dinah W.Y. Sa

Journal:

Journal of Controlled Release

Année:

2010

Langue:

english

Fichier:

PDF, 861 KB

english, 2010

12

2′-Carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation

Muthiah Manoharan

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Année:

1999

Langue:

english

Fichier:

PDF, 361 KB

english, 1999

13

Automated parallel synthesis of 5′-triphosphate oligonucleotides and preparation of chemically modified 5′-triphosphate small interfering RNA

Zlatev, Ivan, Lackey, Jeremy G., Zhang, Ligang, Dell, Amy, McRae, Kathy, Shaikh, Sarfraz, Duncan, Richard G., Rajeev, Kallanthottathil G., Manoharan, Muthiah

Journal:

Bioorganic & Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 1.46 MB

english, 2013

14

Synthesis of Antisense Oligonucleotides Conjugated to a Multivalent Carbohydrate Cluster for Cellular Targeting

Maier, Martin A., Yannopoulos, Constantin G., Mohamed, Nazim, Roland, Arlene, Fritz, Hans, Mohan, V., Just, George, Manoharan, Muthiah

Journal:

Bioconjugate Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 222 KB

english, 2003

15

Synthesis of Chimeric Oligonucleotides Containing Phosphodiester, Phosphorothioate, and Phosphoramidate Linkages

Maier, Martin A., Guzaev, Andrei P., Manoharan, Muthiah

Journal:

Organic Letters

Année:

2000

Langue:

english

Fichier:

PDF, 75 KB

english, 2000

16

Branched Multifunctional Polyether Polyketals: Variation of Ketal Group Structure Enables Unprecedented Control over Polymer Degradation in Solution and within Cells

Shenoi, Rajesh A., Narayanannair, Jayaprakash K., Hamilton, Jasmine L., Lai, Benjamin F. L., Horte, Sonja, Kainthan, Rajesh K., Varghese, Jos P., Rajeev, Kallanthottathil G., Manoharan, Muthiah, Kizha

Journal:

Journal of the American Chemical Society

Année:

2012

Langue:

english

Fichier:

PDF, 3.54 MB

english, 2012

17

Efficient Solid-Phase Chemical Synthesis of 5′-Triphosphates of DNA, RNA, and their Analogues

Zlatev, Ivan, Lavergne, Thomas, Debart, Françoise, Vasseur, Jean-Jacques, Manoharan, Muthiah, Morvan, François

Journal:

Organic Letters

Année:

2010

Langue:

english

Fichier:

PDF, 654 KB

english, 2010

18

Allyl Group as a Protecting Group for Internucleotide Phosphate and Thiophosphate Linkages in Oligonucleotide Synthesis: Facile Oxidation and Deprotection Conditions

Manoharan, Muthiah, Lu, Yixin, Casper, Martin D., Just, George

Journal:

Organic Letters

Année:

2000

Langue:

english

Fichier:

PDF, 74 KB

english, 2000

19

Direct CNS Delivery of siRNA Mediates Robust Silencing in Oligodendrocytes

Querbes, William, Ge, Pei, Zhang, Wenjun, Fan, Yupeng, Costigan, Jason, Charisse, Klaus, Maier, Martin, Nechev, Lubomir, Manoharan, Muthiah, Kotelianski, Victor, Sah, Dinah W.Y.

Journal:

Oligonucleotides

Année:

2009

Langue:

english

Fichier:

PDF, 413 KB

english, 2009

20

Oligonucleotide Conjugates: Alteration of the Pharmacokinetic Properties of Antisense Agents

Manoharan, Muthiah, Tivel, Kathleen, Andrade, Laura, Mohan, V., Condon, Thomas, Bennett, C. Frank, Cook, P. Dan

Journal:

Nucleosides Nucleotides & Nucleic Acids

Année:

1995

Langue:

english

Fichier:

PDF, 292 KB

english, 1995

21

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

Wittrup, Anders, Ai, Angela, Liu, Xing, Hamar, Peter, Trifonova, Radiana, Charisse, Klaus, Manoharan, Muthiah, Kirchhausen, Tomas, Lieberman, Judy

Journal:

Nature Biotechnology

Année:

2015

Langue:

english

Fichier:

PDF, 2.30 MB

english, 2015

22

The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation

Mobin, Mehrpouya B., Gerstberger, Stefanie, Teupser, Daniel, Campana, Benedetta, Charisse, Klaus, Heim, Markus H., Manoharan, Muthiah, Tuschl, Thomas, Stoffel, Markus

Journal:

Nature Communications

Année:

2016

Langue:

english

Fichier:

PDF, 1.89 MB

english, 2016

23

Trends in antibiotic resistance in bacterial keratitis isolates from South India

Lalitha, Prajna, Manoharan, Geetha, Karpagam, Rajaram, Prajna, Namperumalsamy V, Srinivasan, Muthiah, Mascarenhas, Jeena, Das, Manoranjan, Porco, Travis C, Lietman, Thomas M, Cevallos, Vicky, Keenan,

Journal:

British Journal of Ophthalmology

Année:

2017

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2017

24

Molecular dynamics correctly models the unusual major conformation of the GAGU RNA internal loop and with NMR reveals an unusual minor conformation

Spasic, Aleksandar, Kennedy, Scott D., Needham, Laura, Manoharan, Muthiah, Kierzek, Ryszard, Turner, Douglas H., Mathews, David H.

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 2.99 MB

english, 2018

25

Receptor-Specific Delivery of Peptide Nucleic Acids Conjugated to Three Sequentially Linked N-Acetyl Galactosamine Moieties into Hepatocytes

Ganesh, Krishna N., Bhingardeve, Pramod, Madhanagopal, Bharath Raj, jain, prashant, Naick, Hemanth, Manoharan, Muthiah

Journal:

Journal of Organic Chemistry

Année:

2020

Fichier:

PDF, 1.21 MB

2020

26

Improving Antisense Oligonucleotide Binding to Human Serum Albumin: Dramatic Effect of Ibuprofen Conjugation

Muthiah Manoharan, Gopal B. Inamati, Elena A. Lesnik, Namir B. Sioufi, Susan M. Freier

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 186 KB

english, 2002

27

Direct Observation of a Cytosine Analogue that Forms Five Hydrogen Bonds to Guanosine: Guanidino G-Clamp

Christopher J. Wilds, Martin A. Maier, Valentina Tereshko, Muthiah Manoharan, Martin Egli

Journal:

Angewandte Chemie

Année:

2002

Langue:

english

Fichier:

PDF, 92 KB

english, 2002

28

Direct Observation of a Cytosine Analogue that Forms Five Hydrogen Bonds to Guanosine: Guanidino G-Clamp

Christopher J. Wilds, Martin A. Maier, Valentina Tereshko, Muthiah Manoharan, Martin Egli

Journal:

Angewandte Chemie International Edition

Année:

2002

Langue:

english

Fichier:

PDF, 93 KB

english, 2002

29

Electrochemical Detection of Surface Hybridization of Oligodeoxynucleotides Bearing Anthraquinone Tags at Gold Electrodes

Vilmos Kertesz, Neil A. Whittemore, Gopal B. Inamati, Muthiah Manoharan, P. Dan Cook, David C. Baker, James Q. Chambers

Journal:

Electroanalysis

Année:

2000

Langue:

english

Fichier:

PDF, 146 KB

english, 2000

30

Unique Gene-Silencing and Structural Properties of 2′-Fluoro-Modified siRNAs

Dr. Muthiah Manoharan, Dr. Akin Akinc, Dr. Rajendra K. Pandey, June Qin, Dr. Philipp Hadwiger, Dr. Matthias John, Kathy Mills, Dr. Klaus Charisse, Dr. Martin A. Maier, Dr. Lubomir Nechev, Emily M. Gre

Journal:

Angewandte Chemie

Année:

2011

Langue:

english

Fichier:

PDF, 793 KB

english, 2011

31

ChemInform Abstract: Conjugation of Oligonucleotides via an Electrophilic Tether: N-Chloroacetamidohexyl Phosphoramidite Reagent.

Andrei Guzaev, Muthiah Manoharan

Journal:

Année:

1999

Fichier:

PDF, 24 KB

1999

32

ChemInform Abstract: A New, Efficient Exocyclic Amine Protection Scheme for 2-Aminoadenosine and Derivatives for Incorporation into Oligonucleotides

Bruce S. Ross, Robert H. Springer, Ramesh Bharadwaj, Alice M. Symons, Muthiah Manoharan

Journal:

Année:

1999

Fichier:

PDF, 25 KB

1999

33

ChemInform Abstract: A New Protecting Group Strategy for Amino Groups in Oligonucleotide Chemistry: CEOC Group

Muthiah Manoharan, Thazha P. Prakash, Isabelle Barber-Peoc'h, Balkrishen Bhat, Guillermo Vasquez, Bruce S. Ross, Cook P. Dan Cook P. Dan

Journal:

Année:

1999

Fichier:

PDF, 25 KB

1999

34

ChemInform Abstract: Use of [4,6-Di-14C]-5′-DMT-thymidine Phosphoramidite Reagent for the Radiolabeling of Synthetic Oligonucleotides

Andrei Guzaev, Brunel Boyode, Guity Balow, Muthiah Manoharan

Journal:

Année:

1999

Fichier:

PDF, 28 KB

1999

35

ChemInform Abstract: Synthesis of Chimerical Oligonucleotides Containing Internucleosidic Phosphodiester and S-Pivaloyl Mercaptoethyl Phosphotriester Linkages

Andrei Guzaev, Guity Balow, Muthiah Manoharan

Journal:

Année:

1999

Fichier:

PDF, 24 KB

1999

36

ChemInform Abstract: Synthesis, Hybridization, and Nuclease Resistance Properties of 2′-O-Aminooxyethyl Modified Oligonucleotides

Andrew M. Kawasaki, Martin D. Casper, Thazha P. Prakash, Sheri Manalili, Henri Sasmor, Muthiah Manoharan, P. Dan Cook

Journal:

Année:

1999

Fichier:

PDF, 26 KB

1999

37

ChemInform Abstract: Synthesis of Fully Protected Nucleoside-Folic Acid Conjugated Phosphoramidites and Their Incorporation into Antisense Oligonucleotides

Balkrishen Bhat, Guity Balow, Andrei Guzaev, P. Dan Cook, Muthiah Manoharan

Journal:

Année:

1999

Fichier:

PDF, 25 KB

1999

38

ChemInform Abstract: N-(2-Cyanoethoxycarbonyloxy)succinimide: A New Reagent for Protection of Amino Groups in Oligonucleotides.

Muthiah Manoharan, Thazha P. Prakash, Isabelle Barber-Peoc'h, Balkrishen Bhat, Guillermo Vasquez, Bruce S. Ross, P. Dan Cook

Journal:

Année:

2000

Fichier:

PDF, 25 KB

2000

39

ChemInform Abstract: Allyl Group as a Protecting Group for Internucleotide Phosphate and Thiophosphate Linkages in Oligonucleotide Synthesis: Facile Oxidation and Deprotection Conditions.

Muthiah Manoharan, Yixin Lu, Martin D. Casper, George Just

Journal:

Année:

2000

Fichier:

PDF, 25 KB

2000

40

ChemInform Abstract: An Efficient Method for the Synthesis of 2′-O-Modified Nucleosides via Double Alkylation Using Cyclic Sulfates.

Allister S. Fraser, Andrew M. Kawasaki, Michael E. Jung, Muthiah Manoharan

Journal:

Année:

2000

Fichier:

PDF, 31 KB

2000

41

ChemInform Abstract: Zwitterionic Oligonucleotides with 2′-O-[3-(N,N-Dimethylamino)propyl]-RNA Modification: Synthesis and Properties.

Thazha P. Prakash, Muthiah Manoharan, Allister S. Fraser, Andrew M. Kawasaki, Elena A. Lesnik, Stephen R. Owens

Journal:

Année:

2000

Fichier:

PDF, 25 KB

2000

42

ChemInform Abstract: 2′-O-{2-[N,N-(Dialkyl)aminooxy]ethyl}-Modified Antisense Oligonucleotides.

Thazha P. Prakash, Muthiah Manoharan, Andrew M. Kawasaki, Elena A. Lesnik, Stephen R. Owens, Guillermo Vasquez

Journal:

Année:

2001

Fichier:

PDF, 27 KB

2001

43

ChemInform Abstract: A New Approach for the Synthesis of 3′-Deoxy-3′-C-formyl-ribonucleosides and the Synthesis of Alternating Methylene(methylimino) Linked Phosphodiester Backbone Oligonucleotides with 2′-OH and 2′-OMe Groups.

Marija Prhavc, George Just, Balkrishen Bhat, P. Dan Cook, Muthiah Manoharan

Journal:

Année:

2001

Fichier:

PDF, 34 KB

2001

44

ChemInform Abstract: 2-Benzamidoethyl Group — A Novel Type of Phosphate Protecting Group for Oligonucleotide Synthesis.

Andrei P. Guzaev, Muthiah Manoharan

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 31 KB

english, 2001

45

ChemInform Abstract: Inhibition of (Cytosine C5)-Methyltransferase by Oligonucleotides Containing Flexible (Cyclopentane) and Conformationally Constrained (Bicyclo[3.1.0]hexane) Abasic Sites

Victor E. Marquez, Peiyuan Wang, Marc C. Nicklaus, Martin Maier, Muthiah Manoharan, Judith K. Christman, Nilesh K. Banavali, Alexander D. Mackerell Jr.

Journal:

Année:

2001

Fichier:

PDF, 28 KB

2001

46

ChemInform Abstract: A Novel Protecting Strategy for Internucleosidic Phosphate and Phosphorothioate Groups

Andrei P. Guzaev, Muthiah Manoharan

Journal:

Année:

2001

Fichier:

PDF, 24 KB

2001

47

2′-O-[2-(Amino)-2-oxoethyl] Oligonucleotides.

Thazha P. Prakash, Andrew M. Kawasaki, Elena A. Lesnik, Stephen R. Owens, Muthiah Manoharan

Journal:

Année:

2003

Fichier:

PDF, 4 KB

2003

48

2′-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects.

Marija Prhavc, Thazha P. Prakash, George Minasov, P. Dan Cook, Martin Egli, Muthiah Manoharan

Journal:

Année:

2003

Fichier:

PDF, 51 KB

2003

49

MicroRNA-194 is a target of transcription factor 1 (Tcf1, HNF1α) in adult liver and controls expression of frizzled-6

Jan Krützfeldt, Nora Rösch, Jean Hausser, Muthiah Manoharan, Mihaela Zavolan, Markus Stoffel

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 793 KB

english, 2012

50

Structural Basis for Recognition of Guanosine by a Synthetic Tricyclic Cytosine Analogue: Guanidinium G-Clamp

Christopher J. Wilds, Martin A. Maier, Muthiah Manoharan, Martin Egli

Journal:

Helvetica Chimica Acta

Année:

2003

Langue:

english

Fichier:

PDF, 275 KB

english, 2003